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INHIBITORY BINDING OF ADENOSINE DIPHOSPHORIBOSYL TRANSFERASE TO THE DNA PRIMER SITE OF REVERSE-TRANSCRIPTASE TEMPLATES

被引：12
作者：
BUKI, KG
BAUER, PI
KUN, E
机构：
[1] SAN FRANCISCO STATE UNIV,ENVIRONM TOXICOL & CHEM LAB,SAN FRANCISCO,CA 94132
[2] SAN FRANCISCO STATE UNIV,ROMBERG TIBURON CTR,OCTAMER RES FDN,SAN FRANCISCO,CA 94132
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 02期
关键词：
D O I：
10.1016/S0006-291X(05)81092-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purified adenosine diphosphoribose transferase protein binds to RNA-DNA hybrid templates of reverse transcriptase at the DNA primer site and inhibits RT activity of HIV and MMu RTs. This action is prevented by auto-poly-ADP-ribosylation of the transferase but is reinduced by inhibitory ligands of the enzyme. © 1991 Academic Press, Inc.
引用
收藏
页码：496 / 503
页数：8
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