CHRONIC SYSTEMIC DELIVERY OF INSULIN THROUGH THE OCULAR ROUTE

被引：21

作者：

CHIOU, GCY

LI, BHP

机构：

[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University College of Medicine, Texas, College Station

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1993年 / 9卷 / 01期

关键词：

D O I：

10.1089/jop.1993.9.85

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Eyedrops of 0.25% insulin plus 0.5% BL-9 or Brij-78 were instilled into rabbit eyes twice a day for 3 months. It was found that the efficacy of insulin to lower the blood glucose concentration and the uptake of insulin into the systemic circulation remained the same throughout the experimental period. No allergic responses or local side effects could be detected, indicating that both insulin and permeation enhancers (BL-9 and Brij-78) are safe for instillation into the eyes for long periods of time. It is concluded that chronic administration of insulin and absorption enhancers into the eyes is a feasible method to replace injections for diabetes treatment.

引用

页码：85 / 90

页数：6

共 9 条

[1]

Chiou G.C.Y., Chuang C.Y., Chang M.S., Reduction of blood glucose concentrations with insulin eyedrops, Diabetes Care, 11, pp. 750-751, (1988)

[2]

Chiou G.C.Y., Chuang C.Y., Chang M.S., Systemic delivery of insulin through eyes to lower the blood glucose concentration, J. Ocular Pharmacol., 5, pp. 81-91, (1989)

[3]

Chiou G.C.Y., Chuang C.Y., Improvement of systemic absorption of insulin through eyes with absorption enhancers, J. Pharm. Sci., 78, pp. 815-818, (1989)

[4]

Chiou G.C.Y., Shen Z.F., Zheng Y.Q., Adjustment of blood sugar levels with insulin and glucagon eyedrops in normal and diabetic rabbits, J. Ocular Pharmacol., 6, pp. 233-241, (1990)

[5]

Chiou G.C.Y., Systemic delivery of polypeptide drugs through ocular route, Ann. Rev. Pharmacol. Toxicol., 31, pp. 457-467, (1991)

[6]

Yamamoto A., Luo A.M., Dodda-Kashi S., Lee V.H.L., The ocular route for systemic delivery in the albino rabbit, J. Pharmacol. Exp. Therap., 249, pp. 249-255, (1989)

[7]

Pillion D.J., Bartlett J.D., Meezan E., Yang M., Crain R.J., Grizzle W.E., Systemic absorption of insulin delivered topically to the rat eye, Invest. Ophthalmol. Vis. Sci., 32, pp. 3021-3027, (1991)

[8]

Draize J.H., Woodard G., Galvery H.O., Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes, J. Pharmacol. Exp. Ther., 82, pp. 377-390, (1944)

[9]

Gardner S.K., Ocular drug penetration and pharmacokinetic principles, pp. 1-52, (1987)

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