YAC TRANSGENICS AND THE STUDY OF GENETICS AND HUMAN-DISEASE

被引：45

作者：

LAMB, BT

GEARHART, JD

机构：

[1] Division of Developmental Genetics, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287-2501, 600 North Wolfe Street

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-437X(95)80049-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Advances in yeast artificial chromosome (YAC) technologies over the past decade have enabled the precise identification and manipulation of large genomic regions (>100 kb) of DNA. Introduction of YACs into the mouse germline has now been accomplished through transfection of mouse embryonic stem cells as well as through pronuclear microinjection, allowing the efficient transfer of defined genomic loci into mice. YAC transgenics will have a profound impact on the development of transgenic mice as bioreactors and as models of human disease, and on the functional analysis of higher order genomic structure.

引用

页码：342 / 348

页数：7

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