CYCLOPHOSPHAMIDE-ASSOCIATED CARCINOMA OF UROTHELIUM - MODALITIES FOR PREVENTION

被引：27

作者：

CANNON, J ^{[1
]}

LINKE, CA ^{[1
]}

COS, LR ^{[1
]}

机构：

[1] UNIV ROCHESTER,SCH MED & DENT,DEPT UROL,ROCHESTER,NY 14627

来源：

UROLOGY | 1991年 / 38卷 / 05期

关键词：

D O I：

10.1016/0090-4295(91)80228-Y

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The relationship between the cyclophosphamide metabolite acrolein and hemorrhagic cystitis is well documented. Its role in inducing bladder cancer is not clear. There are at least 35 cases of cyclophosphamide-associated bladder cancer in the literature to date. We report 3 additional cases of transitional cell carcinoma of the bladder. Literature assessing the relative risk of bladder cancer associated with cyclophosphamide therapy is reviewed as are methods for decreasing the toxic effects on the urothelium of the metabolite acrolein.

引用

页码：413 / 416

页数：4

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