DETECTION OF INFLAMMATORY LESIONS WITH RADIOLABELED IMMUNOGLOBULINS

被引：26

作者：

BLOK, D

VONOGTROP, M

ARNDT, JW

CAMPS, JAJ

FEITSMA, RIJ

GOEDEMANS, W

PAUWELS, EKJ

机构：

[1] STATE UNIV LEIDEN HOSP,PHARMACOL & TOXICOL CLIN,2333 AA LEIDEN,NETHERLANDS

[2] STATE UNIV LEIDEN HOSP,INFECT DIS CLIN,2333 AA LEIDEN,NETHERLANDS

[3] MALLINCKRODT DIAGNOST HOLLAND BV,1755 ZG PETTEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1990年 / 16卷 / 4-6期

关键词：

!sup]99m[!/sup]Tc labelling; Immunoglobulins; Infection; Inflammation;

D O I：

10.1007/BF00842784

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium. © 1990 Springer-Verlag.

引用

页码：303 / 305

页数：3

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