DIPLOID PREDOMINANCE AND PROGNOSTIC-SIGNIFICANCE OF S-PHASE CELLS IN MALIGNANT MESOTHELIOMA

被引：27

作者：

PYRHONEN, S

LAASONEN, A

TAMMILEHTO, L

RAUTONEN, J

ANTTILA, S

MATTSON, K

HOLSTI, LR

机构：

[1] UNIV HELSINKI,CENT HOSP,DEPT PULM MED,SF-00290 HELSINKI 29,FINLAND

[2] UNIV HELSINKI,CENT HOSP,DEPT MICROBIOL IMMUNOL,SF-00290 HELSINKI 29,FINLAND

[3] INST OCCUPAT HLTH,SF-00290 HELSINKI 29,FINLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 02期

关键词：

D O I：

10.1016/0277-5379(91)90487-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

70 histologically verified, malignant mesotheliomas were analysed by flow cytometry for DNA content and S-phase fraction (SPF) of tumour cells. 60% (42/70) were DNA diploid. 18 of the 28 aneuploid tumours were near-diploid with DNA indices of 1.3 or less. SPF could be calculated in 51 cases. SPF was significantly higher in aneuploid (median 16.0%) than in diploid tumours (median 5.6%). DNA ploidy was not a prognostic determinant; survival was the same for both aneuploid and diploid tumours. SPF, however, was significantly correlated (P = 0.039) with prognosis. Patients who had tumours with a low SPF survived almost twice as long as those with a high SPF. Thus malignant mesothelioma has a peculiar DNA ploidy pattern compared with many other solid tumours, with a predominance of diploid or near-diploid type cells. As in many other tumours, SPF may be used as a clinically relevant prognostic indicator.

引用

页码：197 / 200

页数：4

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