INCREASED SENSITIVITY TO NEUROTENSIN IN FASTED RATS

被引：21

作者：

QUIRION, R

RIOUX, F

STPIERRE, S

REGOLI, D

机构：

[1] Department of Physiology and Pharmacology, Faculty of Medicine, University of Sherbrooke, Sherbrooke

来源：

LIFE SCIENCES | 1979年 / 25卷 / 23期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(79)90600-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study was designed to investigate the influence of fasting on the ability of neurotensin (NT) to produce hypotension in anesthetized rats, to constrict the coronary vessels of perfused rat hearts and to stimulate isolated rat stomach strips and spontaneously beating atria of rats. The hypotensive effects of NT, in contrast to those elicited by bradykinin and isoproterenol, were markedly increased in 24h-fasted and 72h-fasted rats compared to control fed rats. The increase in perfusion pressure provoked by NT in perfused hearts derived from 24h-fasted and 72h-fasted rats was much larger than in hearts derived from control fed animals. On the other hand, the constrictor action of angiotensin in perfused rat hearts was not altered by fasting. The stimulatory effect of NT in stomach strips and atrial preparations derived from fasted rats was not increased when compared to tissues from control fed animals. It is suggested that prolonged period of fasting in rats may contribute to sensitize the cardiovascular system of these animals to the action of NT. © 1979.

引用

页码：1969 / 1973

页数：5

共 22 条

[1] FLUCTUATIONS IN AFFINITY AND CONCENTRATION OF INSULIN RECEPTORS ON CIRCULATING MONOCYTES OF OBESE PATIENTS - EFFECTS OF STARVATION, REFEEDING, AND DIETING [J].