INFLUENCE OF ALCOHOLS ON THE BETA-CYCLODEXTRIN ACRIDINE COMPLEX

被引：71

作者：

SCHUETTE, JM ^{[1
]}

NDOU, TT ^{[1
]}

DELAPENA, AM ^{[1
]}

MUKUNDAN, S ^{[1
]}

WARNER, IM ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 01期

关键词：

D O I：

10.1021/ja00054a042

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The apparent formation constant calculated for the beta-cyclodextrin/acridine (beta-CD/ACR) complex (287 M-1) reveals a weak association in aqueous solution. An additional weakening of the binding strength between beta-CD and ACR, and subsequent reduction in the previously reported quenching of ACR caused by beta-CD, is observed upon interaction of the complex with selected straight-chain and branched alcohols. Nuclear magnetic resonance data suggest that the equilibrium involves the formation of ternary complexes. This equilibrium apparently leaves a greater number of ACR species accessible to the bulk aqueous environment, resulting in a consequent decrease in the total amount of ACR quenched. Specific mechanisms of interaction are further examined through information provided by steady-state fluorescence and fluorescence lifetime analysis.

引用

页码：292 / 298

页数：7

共 43 条

[1]

Albert A., 1966, ACRIDINES

[2] THERMODYNAMICS OF FORMATION OF INCLUSION-COMPOUNDS IN WATER - ALPHA-CYCLODEXTRIN ALCOHOL ADDUCTS AT 298.15-K [J].