FR901459, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STACHYBOTRYS CHARTARUM NO. 19392 - TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES

被引：52

作者：

SAKAMOTO, K

TSUJII, E

MIYAUCHI, M

NAKANISHI, T

YAMASHITA, M

SHIGEMATSU, N

TADA, T

IZUMI, S

OKUHARA, M

机构：

[1] FUJISAWA PHARMACEUT CO LTD, ANALYT RES LABS, YODOGAWA KU, OSAKA 532, JAPAN

[2] FUJISAWA PHARMACEUT CO LTD, EXPLORATORY RES LABS, TSUKUBA, IBARAKI 30026, JAPAN

[3] FUJISAWA PHARMACEUT CO LTD, PHARMACOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 12期

关键词：

D O I：

10.7164/antibiotics.46.1788

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

FR901459, a novel immunosuppressant, has been isolated from the fermentation broth of Stachybotrys chartarum No. 19392. The molecular formula of FR901459 was determined as C62H111N11O13 FR901459 was found to be a member of the cyclosporin family. However, it is structurally distinct from any other cyclosporins discovered so far, in that Leu is present at position 5 instead of Val. FR901459 was capable of prolonging the survival time of skin allografts in rats with one third the potency of cyclosporin A.

引用

页码：1788 / 1798

页数：11

共 24 条

[1] PRODUCTION OF EXTRACELLULAR ENZYMES AND CYCLOSPORINE BY TOLYPOCLADIUM-INFLATUM AND MORPHOLOGICALLY RELATED FUNGI [J].