SYNTHESIS OF THE NATURALLY-OCCURRING INDOLEQUINONE BE-10988, AN INHIBITOR OF TOPOISOMERASE-2

被引：31

作者：

MOODY, CJ

SWANN, E

机构：

[1] Department of Chemistry, University of Loughborough

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 21期

关键词：

D O I：

10.1039/p19930002561

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis (28% overall yield) of the naturally occurring indolequinone BE 10988 1 is described. The synthesis starts from 4-benzyloxy-5-methoxyindole and involves, as key steps, the use of chlorosulfonyl isocyanate to introduce the amide side-chain into the indole 3-position, followed by thioamide formation and construction of the thiazole ring using a Hantzsch reaction.

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页码：2561 / 2565

页数：5

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