A NOVEL NUCLEOTIDE-BASED THROMBIN INHIBITOR INHIBITS CLOT-BOUND THROMBIN AND REDUCES ARTERIAL PLATELET THROMBUS FORMATION

被引:96
作者
LI, WX
KAPLAN, AV
GRANT, GW
TOOLE, JJ
LEUNG, LLK
机构
[1] GILEAD SCI,353 LAKESIDE DR,FOSTER CITY,CA 94404
[2] STANFORD UNIV,MED CTR,SCH MED,DIV HEMATOL,STANFORD,CA 94305
[3] STANFORD UNIV,MED CTR,SCH MED,DIV CARDIOVASC MED,STANFORD,CA 94305
关键词
D O I
10.1182/blood.V83.3.677.677
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:677 / 682
页数:6
相关论文
共 23 条
[1]   BINDING OF THROMBIN TO SUBENDOTHELIAL EXTRACELLULAR-MATRIX - PROTECTION AND EXPRESSION OF FUNCTIONAL-PROPERTIES [J].
BARSHAVIT, R ;
ELDOR, A ;
VLODAVSKY, I .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (04) :1096-1104
[2]  
BEGUIN S, 1989, THROMB HAEMOSTASIS, V61, P25
[3]   SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN [J].
BOCK, LC ;
GRIFFIN, LC ;
LATHAM, JA ;
VERMAAS, EH ;
TOOLE, JJ .
NATURE, 1992, 355 (6360) :564-566
[4]  
CHESEBRO JH, 1987, AM J CARDIOL, V60, pB10
[5]   IMPORTANCE OF FACTOR-XA IN DETERMINING THE PROCOAGULANT ACTIVITY OF WHOLE-BLOOD CLOTS [J].
EISENBERG, PR ;
SIEGEL, JE ;
ABENDSCHEIN, DR ;
MILETICH, JP .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (05) :1877-1883
[6]   INVIVO ANTICOAGULANT PROPERTIES OF A NOVEL NUCLEOTIDE-BASED THROMBIN INHIBITOR AND DEMONSTRATION OF REGIONAL ANTICOAGULATION IN EXTRACORPOREAL CIRCUITS [J].
GRIFFIN, LC ;
TIDMARSH, GF ;
BOCK, LC ;
TOOLE, JJ ;
LEUNG, LLK .
BLOOD, 1993, 81 (12) :3271-3276
[7]   INTERRUPTION OF ACUTE PLATELET-DEPENDENT THROMBOSIS BY THE SYNTHETIC ANTITHROMBIN D-PHENYLALANYL-L-PROLYL-L-ARGINYL CHLOROMETHYL KETONE [J].
HANSON, SR ;
HARKER, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (09) :3184-3188
[8]   CONTINUOUS INTRAVENOUS HEPARIN COMPARED WITH INTERMITTENT SUBCUTANEOUS HEPARIN IN THE INITIAL TREATMENT OF PROXIMAL-VEIN THROMBOSIS [J].
HULL, RD ;
RASKOB, GE ;
HIRSH, J ;
JAY, RM ;
LECLERC, JR ;
GEERTS, WH ;
ROSENBLOOM, D ;
SACKETT, DL ;
ANDERSON, C ;
HARRISON, L ;
GENT, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (18) :1109-1114
[9]  
JAKUBOWSKI JA, 1990, BLOOD, V75, P399
[10]   ROLES OF THROMBIN AND PLATELET MEMBRANE GLYCOPROTEIN-IIB/IIIA IN PLATELET-SUBENDOTHELIAL DEPOSITION AFTER ANGIOPLASTY IN AN EXVIVO WHOLE ARTERY MODEL [J].
KAPLAN, AV ;
LEUNG, LLK ;
LEUNG, WH ;
GRANT, GW ;
MCDOUGALL, IR ;
FISCHELL, TA .
CIRCULATION, 1991, 84 (03) :1279-1288