CHRONIC SOCIAL STRESS INCREASES LEVELS OF PREPROGALANIN MESSENGER-RNA IN THE RAT LOCUS-COERULEUS

被引:66
作者
HOLMES, PV
BLANCHARD, DC
BLANCHARD, RJ
BRADY, LS
CRAWLEY, JN
机构
[1] NIMH,FUNCT NEUROANAT SECT,CLIN NEUROENDOCRINOL BRANCH,BETHESDA,MD 20892
[2] UNIV HAWAII,JOHN A BURNS SCH MED,DEPT ANAT & REPROD BIOL,HONOLULU,HI 96822
[3] UNIV HAWAII,PACIFIC BIOMED RES CTR,HONOLULU,HI 96822
[4] UNIV HAWAII,DEPT PSYCHOL,HONOLULU,HI 96822
关键词
GALANIN; IN SITU HYBRIDIZATION; VISIBLE BURROW SYSTEM; DOMINANT; SUBORDINATE;
D O I
10.1016/0091-3057(94)00334-3
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Galanin is a 29 amino acid neuropeptide that coexists with norepinephrine in approximately 80% of locus coeruleus (LC) neurons in the rat. The effects of chronic, naturalistic stress on preprogalanin mRNA in the LC was studied. The visible burrow system (VBS) served as the stress paradigm. Long-Evans rats (three males and two females) were housed together in the VBS for 13 days. The males established dominance hierarchies during this period. On day 14, preprogalanin mRNA in the LC was significantly elevated in subordinate rats compared to dominant and control rats, as measured by quantitative in situ hybridization. Levels of mRNA were positively correlated with the number of wounds by day 7 and day 14 and negatively correlated with body weight gain by day 14. These results suggest that the neuropeptide galanin may be overexpressed during chronic stress in rats.
引用
收藏
页码:655 / 660
页数:6
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