PLASMA ATRIAL-NATRIURETIC-PEPTIDE DURING SPONTANEOUS BRONCHOCONSTRICTION IN ASTHMATICS

被引：7

作者：

ROBICHAUD, A

MICHOUD, MC

HAMET, P

DUSOUICH, P

机构：

[1] UNIV MONTREAL,FAC MED,DEPT PHARMACOL,MONTREAL,PQ H3C 3J7,CANADA

[2] HOP HOTEL DIEU,MONTREAL,PQ,CANADA

来源：

PEPTIDES | 1995年 / 16卷 / 04期

基金：

英国医学研究理事会;

关键词：

ATRIAL NATRIURETIC PEPTIDE; ASTHMA; BRONCHOCONSTRICTION HUMANS;

D O I：

10.1016/0196-9781(95)00023-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this work was to establish the role of endogenous ANP during a spontaneous asthma attack. Forced expiratory lung volume in 1 s (FEV1), cardiovascular parameters, and plasma ANP, cAMP, and cGMP were measured for 60 min before and 10 min after treatment with a bronchodilator in IO asthmatics. The results show that in the presence of moderate bronchoconstriction, FEV1 was 54 +/- 3% (+/-SE); ANP levels initially were slightly elevated at 47 +/- 10 pg/ml and decreased to 26 +/- 3 pg/ml (p < 0.05) over 60 min, with no change in FEV1. Following salbutamol inhalation, FEV1 increased to 77 +/- 4% with no change in ANP. We conclude that endogenous ANP does not act as a bronchodilator in asthmatics with moderate bronchospasm.

引用

页码：653 / 656

页数：4

共 25 条

[1] ATRIAL NATRIURETIC FACTOR IN CHRONIC OBSTRUCTIVE LUNG-DISEASE WITH PULMONARY-HYPERTENSION - PHYSIOLOGICAL CORRELATES AND RESPONSE TO PEPTIDE INFUSION [J].