STUDIES ON MURINE SARCOMA VIRUS - ANTIGENIC CHARACTERIZATION OF MURINE SARCOMA VIRUS INDUCED TUMOR CELLS

被引:54
作者
CHUAT, JC
BERMAN, L
GUNVEN, P
KLEIN, E
机构
[1] Institute of Tumor Biology, Karolinska Institutet, Stockholm
[2] Laboratoire d'Hématologie Expérimentale, Institut de Recherches sur les Leucémies, Hopital Saint-Louis, Paris
[3] Channing Laboratory, Mallory Institute of Pathology, Boston City Hospital, Boston, Massachusetts
关键词
D O I
10.1002/ijc.2910040412
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The antigenicity of Murine Sarcoma Virus (MSV) transformed mouse, rat and hamster cells has been studied by several techniques designed to detect surface antigens. Antigens were readily demonstrated on neoplastic mouse and rat cells. There was complete cross‐reactivity between cells induced by the Harvey (MSV‐H) or Moloney (MSV‐M) strains of MSV and by Moloney Leukemia Virus (MLV). No evidence of a distinct or separate „MSV‐non‐MLV” antigen could be obtained by cross absorptions of MSV/MLV antisera and cells, or by tests designed to break MLV tolerance. Such results favor the view that MSV and MLV are closely related entities. With the 8303 line of MSV‐M transformed hamster cells serological tests revealed little if any reactivity with strongly positive mouse anti‐MSV/MLV antisera. In one test, however, immunization of mice with these cells gave some degree of protection against syngeneic MSV sarcoma. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:465 / &
相关论文
共 29 条
[1]   MURINE SARCOMA VIRUS (HARVEY) - CHARACTERISTICS OF FOCUS FORMATION IN MOUSE EMBRYO CELL CULTURES AND VIRUS PRODUCTION BY HAMSTER TUMOR CELLS [J].
BASSIN, RH ;
SIMONS, PJ ;
CHESTERMAN, FC ;
HARVEY, JJ .
INTERNATIONAL JOURNAL OF CANCER, 1968, 3 (02) :265-+
[2]  
BERNARD C, 1967, CR HEBD ACAD SCI, V264, P2120
[3]   PRESENCE IN MURINE SARCOMA VIRUS STOCKS OF A THIRD COMPONENT WHICH ALONE INITIATES CELLULAR CONVERSION [J].
BOIRON, M ;
GUILLEMAIN, B ;
BERNARD, C ;
PERIES, J ;
CHUAT, JC .
NATURE, 1968, 219 (5155) :748-+
[4]  
DALTON AJ, 1966, 22 NAT CANC I MON, P143
[5]  
FEFER A, 1967, CANCER RES, V27, P962
[6]  
FEFER A, 1967, CANCER RES, V27, P2202
[7]  
FENYO EM, 1968, J NATL CANCER I, V40, P69
[8]  
FIENNES RNT, 1966, SOME RECENT DEVEL ED, P251
[9]  
GUILLEMAIN B, 1968, CR ACAD SCI D NAT, V266, P1088
[10]   VIRUS PARTICLES AND MURINE LEUKEMIA VIRUS COMPLEMENT-FIXING ANTIGEN IN NEOPLASTIC AND NONNEOPLASTIC CELL LINES [J].
HALL, WT ;
ANDRESEN, WF ;
SANFORD, KK ;
EVANS, VJ ;
HARTLEY, JW .
SCIENCE, 1967, 156 (3771) :85-&