CYTOTOXIC, MUTAGENIC AND CLASTOGENIC EFFECTS OF CHROMIUM-CONTAINING COMPOUNDS ON MAMMALIAN-CELLS IN CULTURE

被引：74

作者：

NEWBOLD, RF

AMOS, J

CONNELL, JR

机构：

[1] Institute of Cancer Research: Pollards Wood Research Station, Chemical Carcinogenesis Division, Chalfont St. Giles,, Buckinghamshire Buckinghamshire HP8 4SP, Nightingales Lane

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0165-1218(79)90099-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Examples of chromic and chromate salts have been examined for their effects on a cultured Chinese hamster cell line. The responses studied were cytotoxicity, mutagenesis and clastogenesis. Chromate (hexavalent chromium) salts of both high and medium water solubility were active in producing all three classes of response, whereas an insoluble chromate salt and a soluble chromic (trivalent chromium) salt were inactive. In addition to illustrating the value of using mammalian cells in culture for screening chemicals for biological activity, the results of this study reinforce current views regarding the genotoxic properties of chromates. © 1979.

引用

页码：55 / 63

页数：9

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