EFFECT OF TRIETHYLLEAD ON TOTAL AND MYELIN PROTEIN-SYNTHESIS IN RAT FOREBRAIN SLICES

被引：20

作者：

KONAT, G

OFFNER, H

CLAUSEN, J

机构：

[1] The Neurochemical Institute, Copenhagen, DK-2200, 58, Rådmandsgade

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 01期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb04526.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rats (20‐day‐old) were acutely intoxicated with triethyllead and their forebrains were studied during the following 14 days. All the lead in the tissue was found in the form of triethyllead, proving that the toxin per se was responsible for the pathological changes observed in the organ. The incorporation of [14C]leucine into the acid‐insoluble protein was suppressed in the forebrain slices prepared from the intoxicated animals as well as in the slices, to which PbEt3 was added in vitro. In both systems the synthesis of myelin protein was inhibited more than the total protein synthesis. The results suggest a specificity of triethyllead toward processes involved in the furnishing of the myelin membrane proteins. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：187 / 190

页数：4

共 13 条

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KONAT, G
CLAUSEN, J
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[9] TRIETHYLLEAD-RESTRAINED MYELIN DEPOSITION AND PROTEIN-SYNTHESIS IN DEVELOPING RAT FOREBRAIN
KONAT, G
OFFNER, H
CLAUSEN, J
[J]. EXPERIMENTAL NEUROLOGY, 1976, 52 (01) : 58 - 65
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