6-METHYLANGELICINS - NEW MONOFUNCTIONAL PHOTOCHEMOTHERAPEUTIC AGENTS FOR PSORIASIS

被引：24

作者：

CRISTOFOLINI, M

RECCHIA, G

BOI, S

PISCIOLI, F

BORDIN, F

BACCICHETTI, F

CARLASSARE, F

TAMARO, M

PANI, B

BABUDRI, N

GUIOTTO, A

RODIGHIERO, P

VEDALDI, D

DALLACQUA, F

机构：

[1] UNIV TRIESTE,INST MICROBIOL,TRIESTE,ITALY

[2] UNIV TRIESTE,DEPT BIOCHEM BIOPHYS & MACROMOLEC CHEM,TRIESTE,ITALY

[3] UNIV PADUA,DEPT PHARMACEUT SCI,I-35100 PADUA,ITALY

[4] HOSP SANTA CHIARA,INST ANAT PATHOL,TRENT,ITALY

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1990年 / 122卷 / 04期

关键词：

D O I：

10.1111/j.1365-2133.1990.tb14728.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The monofunctional furocoumarins, the 6-methylangelicins, were tested for their antiproliferative activity with various animal models and for genotoxicity in micro-organisms and in mammalian cells. The most active compound was 6,4,4'-trimethylangelicin, which showed a high antiproliferative effect and reduced genotoxicity in comparison with 8-methoxypsoralen (8-MOP). Some of these compounds were also tested clinically by topical application on 17 patients with psoriasis. They appeared to be more active than 8-MOP in clearing psoriasis without inducing skin phototoxicity. The methylangelicins also caused skin pigmentation

引用

页码：513 / 524

页数：12

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