HISTIOCYTOSIS-X - CLINICAL-TRIAL OF CHLORAMBUCIL - A REPORT FROM CHILDRENS-CANCER-STUDY-GROUP

被引：7

作者：

LAHEY, ME

HEYN, RM

NEWTON, WA

SHORE, N

SMITH, WB

LEIKIN, S

HAMMOND, D

机构：

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 7卷 / 03期

关键词：

chlorambucil; histiocytosis X;

D O I：

10.1002/mpo.2950070302

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A prospective study for histiocytosis X was designed to determine whether “good risk” patients, ie, those without evidence of dysfunction of liver, lung, or hemopoietic system, would respond to single agent therapy; in this case chlorambucil (CMB) used in a dose of 5 mgm/m2 /day. If there was no response after an adequate trial period, treatment was initiated with four drugs using a combination of prednisone, vinblastine, cyclophosphamide and methotrexate. There were 26 evaluable patients, 57% of whom were less than two years of age at onset of therapy. There were three complete and four partial responses to CMB for a response rate of 26.9%. Sixteen patients received an adequate trial of four‐drug therapy with three complete and two partial responses for a response rate of 33%. These responses were inferior to those previously reported for either single agents or combined therapy in histiocytosis X. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：197 / 203

页数：7

共 7 条

[1]

Lahey ME, Histiocytosis X – An analysis of prognostic factors, J Pediatr, 87, pp. 184-189, (1975)

[2]

Starling KA, Fernbach DJ, Histiocytosis, Clinical Pediatric Oncology, (1973)

[3]

Starling KA, Donaldson MH, Haggard ME, Vietti T, Sutow WW, Therapy of histiocytosis with vincristine, vinblastine and cyclophosphamide, Am J Dis Child, 123, pp. 105-110, (1972)

[4]

Lahey ME, Histiocytosis X – Comparison of three treatment regimens, J Pediatr, 87, pp. 179-183, (1975)

[5]

Smith PJ, Ekert H, Campbell PE, Improved prognosis in disseminated histiocytosis, Med Pediatr Oncol, 2, pp. 371-377, (1976)

[6]

Lahey ME, Prognosis in reticuloendotheliosis in children, J Pediatr, 60, pp. 664-671, (1962)

[7]

Komp D, Vietti TJ, Berry DH, Starling KA, Haggard ME, George SL, Combination chemotherapy in histiocytosis X, Med Pediatr Oncol, 3, pp. 267-273, (1977)

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