INVIVO UNWINDING FLUOROMETRIC ASSAY AS EVIDENCE OF THE DAMAGE INDUCED BY FENARIMOL AND DNOC IN RAT-LIVER DNA

被引：22

作者：

GRILLI, S

ANCORA, G

RANI, P

VALENTI, AM

MAZZULLO, M

COLACCI, A

机构：

[1] UNIV BOLOGNA,IST CANC,I-40126 BOLOGNA,ITALY

[2] UNIV BOLOGNA,IST CANCEROL,SEZ BIOTECHNOL,IST GENOVA,IST NAZL RIC CANC,I-40126 BOLOGNA,ITALY

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1991年 / 34卷 / 04期

关键词：

D O I：

10.1080/15287399109531584

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Five pesticides [amitraz, cyanazine, cyhexatin, dinitro-o-cresol (DNOC), and fenarimol] were tested as pure active ingredients for in vivo induction of DNA strand breaks on rat hepatocytes after intraperitoneal (ip) treatment. Two pesticides, fenarimol and DNOC, were capable of inducing DNA damage because they significantly increased the DNA unwinding rate. On the contrary, amitraz, cyanazine, and cyhexatin were not DNA-damaging agents.

引用

页码：485 / 494

页数：10

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