INDUCTION OF METALLOTHIONEIN BY SIMULTANEOUS ADMINISTRATION OF CADMIUM(II) AND ZINC(II)

被引：19

作者：

HARFORD, C

SARKAR, B

机构：

[1] HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ONTARIO,CANADA

[2] UNIV TORONTO,DEPT BIOCHEM,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91971-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LLC-PK1 cells were used as a model of renal proximal tubule cells in the induction of metallothionein by cadmium(II) and zinc(II). We have found that the induction of metallothionein by either cadmium(II) or zinc(II) alone reaches a maximum which cannot be surpassed by increased amounts of the same metal. However, induction is additive when the cells are exposed to the two metals simultaneously. This indicates that the induction of metallothionein by cadmium(II) and by zinc(II) occurs by different mechanisms within these cells. © 1991.

引用

页码：224 / 228

页数：5

共 10 条

[1]

GARVEY JS, 1982, METHOD ENZYMOL, V84, P121

[2]

GSTRAUNTHALER GJA, 1988, RENAL PHYSIOL BIOCH, V11, P1

[3] METALLOTHIONEIN [J].