ZYMOSAN INDUCES SELECTIVE RELEASE OF ARACHIDONIC-ACID FROM RABBIT ALVEOLAR MACROPHAGES VIA STIMULATION OF A BETA-GLUCAN RECEPTOR

被引：35

作者：

DAUM, T ^{[1
]}

ROHRBACH, MS ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN, THORAC DIS RES UNIT, ROOM 621C, GUGGENHEIM BLDG, ROCHESTER, MN 55905 USA

来源：

FEBS LETTERS | 1992年 / 309卷 / 02期

关键词：

ZYMOSAN; BETA-GLUCAN; ALPHA-MANNAN; ALVEOLAR MACROPHAGE; ARACHIDONIC ACID METABOLISM;

D O I：

10.1016/0014-5793(92)81077-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zymosan, which is composed primarily of alpha-mannan and beta-glucan polymers. is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate beta-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble beta-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble beta-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. Beta-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a beta-glucan receptor.

引用

页码：119 / 122

页数：4

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