A NEW CONVENIENT PROCEDURE FOR THE SYNTHESIS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINES

被引：15

作者：

COURTNEY, SM ^{[1
]}

THURSTON, DE ^{[1
]}

机构：

[1] UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DIV MED CHEM,PK BLDG,KING HENRY I ST,PORTSMOUTH PO1 2DZ,HANTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)73987-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) ring system based on a new cyclisation procedure is reported. The parent unsubstituted PBD (4a) and the benzyl derivative (4b) of the natural product DC-81 (4c) have been synthesized to illustrate the utility of this procedure.

引用

页码：5327 / 5328

页数：2

共 10 条

[1]

BOSE DS, 1992, TETRAHEDRON, V48, P751

[2] DESIGN AND SYNTHESIS OF POTENTIAL DNA CROSS-LINKING REAGENTS BASED ON THE ANTHRAMYCIN CLASS OF MINOR GROOVE BINDING-COMPOUNDS [J].