HUMAN-LEUKOCYTE ANTIGEN (HLA) AND MALARIA MORBIDITY IN A GAMBIAN COMMUNITY

被引：23

作者：

BENNETT, S

ALLEN, SJ

OLERUP, O

JACKSON, DJ

WHEELER, JG

ROWE, PA

RILEY, EM

GREENWOOD, BM

机构：

[1] MRC,BANJUL,SENEGAMBIA

[2] KAROLINSKA INST,NOVUM,CTR BIOTECHNOL,S-14186 HUDDINGE,SWEDEN

[3] UK TRANSPLANT SUPPORT SERV AUTHOR,BRISTOL BS10 5ND,ENGLAND

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1993年 / 87卷 / 03期

关键词：

D O I：

10.1016/0035-9203(93)90130-I

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Human leucocyte antigen (HLA) class I and class II typing was performed on 177 children in a rural area of The Gambia who were followed for 2 years in a longitudinal study of malaria morbidity. A comparison was made between those who experienced an episode of clinical malaria in one or both years and those who showed no evidence of infection in either year. No convincing association was found between morbidity and class I phenotype. An overall association of morbidity with the distribution of class II haplotypes was seen, but associations with individual DR-DQ haplotypes were not conclusive.

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页码：286 / 287

页数：2

相关论文

共 8 条

[1]

BODMER WF, 1989, HISTOCOMPATIBILITY T, V1, P72

[2] SOME STATISTICAL METHODOLOGY FOR THE ANALYSIS OF HLA DATA [J].

FAREWELL, VT ;

DAHLBERG, S .

BIOMETRICS, 1984, 40 (02) :547-560

[3] MORTALITY AND MORBIDITY FROM MALARIA AMONG CHILDREN IN A RURAL AREA OF THE GAMBIA, WEST-AFRICA [J].

GREENWOOD, BM ;

BRADLEY, AK ;

GREENWOOD, AM ;

BYASS, P ;

JAMMEH, K ;

MARSH, K ;

TULLOCH, S ;

OLDFIELD, FSJ ;

HAYES, R .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (03) :478-486

[4] COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA [J].

HILL, AVS ;

ALLSOPP, CEM ;

KWIATKOWSKI, D ;

ANSTEY, NM ;

TWUMASI, P ;

ROWE, PA ;

BENNETT, S ;

BREWSTER, D ;

MCMICHAEL, AJ ;

GREENWOOD, BM .

NATURE, 1991, 352 (6336) :595-600

[5] HLA-DR AND HLA-DQ GENE POLYMORPHISM IN WEST AFRICANS IS TWICE AS EXTENSIVE AS IN NORTH EUROPEAN CAUCASIANS - EVOLUTIONARY IMPLICATIONS [J].

OLERUP, O ;

TROYEBLOMBERG, M ;

SCHREUDER, GMT ;

RILEY, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8480-8484

[6] RECOGNITION OF DOMINANT T CELL-STIMULATING EPITOPES FROM THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM AND RELATIONSHIP TO MALARIA MORBIDITY IN GAMBIAN CHILDREN [J].

RILEY, EM ;

ALLEN, SJ ;

BENNETT, S ;

THOMAS, PJ ;

ODONNELL, A ;

LINDSAY, SW ;

GOOD, MF ;

GREENWOOD, BM .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (05) :648-657

[7] MHC AND MALARIA - THE RELATIONSHIP BETWEEN HLA CLASS-II ALLELES AND IMMUNE-RESPONSES TO PLASMODIUM-FALCIPARUM [J].

RILEY, EM ;

OLERUP, O ;

BENNETT, S ;

ROWE, P ;

ALLEN, SJ ;

BLACKMAN, MJ ;

TROYEBLOMBERG, M ;

HOLDER, AA ;

GREENWOOD, BM .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (09) :1055-1063

[8]

TERASAKI PI, 1974, MANUAL TISSUE TYPING, P67