ELUCIDATION OF CATALYTIC SPECIFICITIES OF HUMAN CYTOCHROME-P450 AND GLUTATHIONE-S-TRANSFERASE ENZYMES AND RELEVANCE TO MOLECULAR EPIDEMIOLOGY

被引：45

作者：

GUENGERICH, FP

SHIMADA, T

RANEY, KD

YUN, CH

MEYER, DJ

KETTERER, B

HARRIS, TM

GROOPMAN, JD

KADLUBAR, FF

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,CTR MOLEC TOXICOL,NASHVILLE,TN 37232

[2] VANDERBILT UNIV,SCH MED,CTR MOLEC TOXICOL,NASHVILLE,TN 37235

[3] VANDERBILT UNIV,SCH MED,DEPT CHEM,NASHVILLE,TN 37235

[4] UNIV LONDON MIDDLESEX HOSP,CRC,MOLEC TOXICOL RES GRP,LONDON W1P 6DB,ENGLAND

[5] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,DIV ENVIRONM CHEM,BALTIMORE,MD 21205

[6] NATL CTR TOXICOL RES,JEFFERSON,AR 72079

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1992年 / 98卷

关键词：

D O I：

10.2307/3431250

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. In some cases a single enzyme can catalyze both activation and detoxication reactions of a chemical. The purification and characterization of human lung P4501A1 and the development of a noninvasive assay for human P4502E1 are also described.

引用

页码：75 / 80

页数：6

共 28 条

[1] 5 OF 12 FORMS OF VACCINIA VIRUS-EXPRESSED HUMAN HEPATIC CYTOCHROME-P450 METABOLICALLY ACTIVATE AFLATOXIN-B1 [J].