A CLINICAL COMPARISON OF CETIRIZINE VERSUS ASTEMIZOLE IN PERENNIAL ALLERGIC RHINITIS

被引:12
作者
CHAWEEWAN, B
JAREONCHAI, P
DHORRANINTRA, B
机构
[1] ENT Department, Faculty of Medicine, Siriraj Hospital, Bangkok
[2] ENT Department, Mahidol University, Bangkok
来源
DRUG INVESTIGATION | 1993年 / 5卷 / 04期
关键词
D O I
10.1007/BF03258450
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The rapidity of action, efficacy and tolerability of cetirizine and astemizole, 2 second generation H-1-receptor antagonists, were investigated in patients in a 1-month double-blind parallel randomised study. 59 patients known to be perennial rhinitis sufferers completed the study; 30 patients received a regimen of cetirizine 10mg and 29 received astemizole 10mg. Symptoms were assessed at days 1, 14 and 28 by the investigator, and were scored daily by the patients. In addition, the H-1 antagonist activity was measured using several allergens, intradermal skin tests and a nasal histamine sensitivity test (NHST). The time to relief of symptoms was recorded by the patients in minutes, hours or days. A 10cm visual analogue scale was used for the assessment of the patients' general condition. The results showed a faster relief of symptoms and a better effect on rhinorrhoea with cetirizine (p < 0.03). NHST was significantly improved with both astemizole and cetirizine compared with baseline data, but there was no significant difference between astemizole and cetirizine. Patients' reports also indicated that cetirizine relieved the symptoms faster than astemizole, at mean times of 0.58 and 13.6 hours, respectively (p < 0.01). Both products were similarly well tolerated, with mild and transient drowsiness affecting 4 of 30 patients taking cetirizine and 4 of 29 patients taking astemizole.
引用
收藏
页码:222 / 228
页数:7
相关论文
共 36 条
[1]  
Alford C., Bhatti J.Z., Rombaut N.E.T., Curran S., Hindmarch I., A comparison of antihistamines using EEG and questionnairebased assessments, Medical Science Research, 17, pp. 421-423, (1989)
[2]  
Braunstein G., Malaquin F., Fajac I., Melac M., Frossard N., Inhibition of histamine-induced nasal obstruction by cetirizine in allergic rhinitis, British Journal of Clinical Pharmacology, 33, pp. 445-448, (1992)
[3]  
Bruttmann G., Arendt C., Bernheim J., Double-blind, placebo controlled comparison of cetirizine HCl and terfenadine in atopic perennial rhinitis, Acta Therapeutica, 15, pp. 99-107, (1989)
[4]  
Bunnag C., Dhorranintra B., Jareoncharsi P., A double-blind parallel study of astemizole and chlorpheniramine in perennial rhinitis, Otolaryngology — Head and Neck Surgery, 4, pp. 1-12, (1989)
[5]  
Capron M., Leprevost C., De Vos C., Tomassini M., Capron A., In vitro activity of cetirizine on eosinophils, Health Science Review, 3, pp. 5-7, (1989)
[6]  
Charlesworth E.N., Kagey-Sobotka A., Norman P.S., Lichtenstein L.M., Effect of cetirizine on mast-cell mediator release and cellular traffic during the cutaneous late-phase reaction, Journal of Allergy and Clinical Immunology, 83, pp. 905-912, (1989)
[7]  
Coulie P., Cetirizine: an overview of clinical efficacy, Health Science Review, 3, pp. 19-22, (1989)
[8]  
Davies B.H., Mullins J., Couch H.A., Prophylactic treatment of seasonal allergic rhinitis. A comparison of cetirizine and terfenadine, Clinical Trials, 26, pp. 100-107, (1989)
[9]  
Dhorranintra B., Liuvan S., Bunnag C., Effect of astemizole on psychomotor performance in healthy Thais, Drug Development Research, 7, pp. 285-290, (1986)
[10]  
Do M., Vanhulle G., Baelde Y., Coulie P., Dupont P., Et al., Lack of potentiation by cetirizine of alcohol-induced psychomotor disturbances, European Journal of Clinical Pharmacology, 34, pp. 619-623, (1988)