OPEN-LOOP CONTROL OF SPECIFIC GROWTH-RATE IN FED-BATCH CULTURES OF RECOMBINANT ESCHERICHIA-COLI

被引：24

作者：

GREGORY, ME ^{[1
]}

TURNER, C ^{[1
]}

机构：

[1] IMPERIAL COLL SCI TECHNOL & MED, CTR PROC SYST ENGN, LONDON SW7, ENGLAND

来源：

BIOTECHNOLOGY TECHNIQUES | 1993年 / 7卷 / 12期

关键词：

D O I：

10.1007/BF00156368

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A computer-based algorithm was used for the open-loop control of specific growth rate in fed-batch cultures of recombinant E.coli.. The control of nutrient feed rate to an exponential trajectory resulted in growth of the culture at a constant specific growth rate. Stable specific growth rates between 0.08 and 0.4 h(-1) were achieved.

引用

页码：889 / 894

页数：6