LIPOSOME TARGETING TO RAT-BRAIN - EFFECT OF OSMOTIC OPENING OF THE BLOOD-BRAIN-BARRIER

被引：38

作者：

SAKAMOTO, A ^{[1
]}

IDO, T ^{[1
]}

机构：

[1] TOHOKU UNIV,CTR CYCLOTRON & RADIOISOTOPE,DIV RADIOPHARMACEUT CHEM,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

BRAIN RESEARCH | 1993年 / 629卷 / 01期

关键词：

BLOOD BRAIN BARRIER; INTRA-CAROTID INJECTION; LIPOSOME; OSMOTIC TREATMENT; SULFATIDE;

D O I：

10.1016/0006-8993(93)90499-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine whether sulfatide liposomes can cross the blood-brain barrier (BBB) with or without osmotic treatment by mannitol, we administered liposomes through the internal carotid artery in rats. Sulfatide liposomes could pass the BBB with osmotic treatment, but not without osmotic treatment. Therefore, we propose that the combination method of administration of the reticuloendothelial-system avoiding liposomes with osmotic treatment can be useful for treatment of various kinds of brain diseases.

引用

页码：171 / 175

页数：5

共 24 条

[1] LIPOSOMES WITH PROLONGED CIRCULATION TIMES - FACTORS AFFECTING UPTAKE BY RETICULOENDOTHELIAL AND OTHER TISSUES [J].

ALLEN, TM ;

HANSEN, C ;

RUTLEDGE, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 981 (01) :27-35

[2] LIPOSOMES CONTAINING SYNTHETIC LIPID DERIVATIVES OF POLY(ETHYLENE GLYCOL) SHOW PROLONGED CIRCULATION HALF-LIVES INVIVO [J].

ALLEN, TM ;

HANSEN, C ;

MARTIN, F ;

REDEMANN, C ;

YAUYOUNG, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1066 (01) :29-36

[3]

ALLEN TM, 1983, J PHARMACOL EXP THER, V226, P539

[4] BLOOD-BRAIN-BARRIER DISRUPTION USING MANNITOL - TIME COURSE AND ELECTRON-MICROSCOPY STUDIES [J].

COSOLO, WC ;

MARTINELLO, P ;

LOUIS, WJ ;

CHRISTOPHIDIS, N .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (02) :R443-R447

[5] NEUROPSYCHOLOGICAL ASSESSMENT OUTCOMES OF NONACQUIRED IMMUNODEFICIENCY SYNDROME PATIENTS WITH PRIMARY CENTRAL-NERVOUS-SYSTEM LYMPHOMA BEFORE AND AFTER BLOOD-BRAIN-BARRIER DISRUPTION CHEMOTHERAPY [J].

CROSSEN, JR ;

GOLDMAN, DL ;

DAHLBORG, SA ;

NEUWELT, EA .

NEUROSURGERY, 1992, 30 (01) :23-29

[6] LIPOSOMAL DRUG DELIVERY - ADVANTAGES AND LIMITATIONS FROM A CLINICAL PHARMACOKINETIC AND THERAPEUTIC PERSPECTIVE [J].

FIELDING, RM .

CLINICAL PHARMACOKINETICS, 1991, 21 (03) :155-164

[7] LIPOSOME FORMULATIONS WITH PROLONGED CIRCULATION TIME IN BLOOD AND ENHANCED UPTAKE BY TUMORS [J].

GABIZON, A ;

PAPAHADJOPOULOS, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6949-6953

[8]

GABIZON AA, 1992, CANCER RES, V52, P891

[9]

GUMERLOCK MK, 1992, J NEURO-ONCOL, V12, P33

[10] DIFFERENTIAL DISTRIBUTION OF LIPOSOME-ENTRAPPED [METHOTREXATE-H-3] AND LABELED LIPIDS AFTER INTRAVENOUS-INJECTION IN A PRIMATE [J].

KIMELBERG, HK .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 448 (04) :531-550

← 1 2 3 →