PEPTIDE-BOND FORMATION VIA CATALYTIC ANTIBODIES - SYNTHESIS OF A NOVEL PHOSPHONATE DIESTER HAPTEN

被引：96

作者：

SMITH, AB ^{[1
]}

TAYLOR, CM ^{[1
]}

BENKOVIC, SJ ^{[1
]}

HIRSCHMANN, R ^{[1
]}

机构：

[1] PENN STATE UNIV,DEPT CHEM,UNIVERSITY PK,PA 16802

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 37期

关键词：

D O I：

10.1016/0040-4039(94)85022-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic alpha-amino phosphonate 4.

引用

页码：6853 / 6856

页数：4

共 18 条

[1]

BENKOVIC SJ, 1992, ANNU REV BIOCHEM, V61, P29

[2]

CARROLL PJ, UNPUB

[3]

ENTZEROTH M, 1983, LIEBIGS ANN CHEM, P226

[4] SYNTHESIS OF AN OPTICALLY ACTIVE ALPHA-AMINOPHOSPHONIC ACID [J].

GILMORE, WF ;

MCBRIDE, HA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (12) :4361-&

[5]

GLOWIAK T, 1977, TETRAHEDRON LETT, V45, P3965

[6]

HIRSCHMANN R, IN PRESS SCIENCE

[7]

HIRSCHMANN R, 1969, J AM CHEM SOC, V91, P509

[8] STRATEGY FOR THE CHEMICAL SYNTHESIS OF LARGE PEPTIDES - SYNTHESIS OF ANGIOGENIN AS AN EXAMPLE [J].

KIMURA, T ;

CHINO, N ;

KUMAGAYE, SI ;

KURODA, H ;

EMURA, J ;

SAKAKIBARA, S .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1990, 18 (06) :1297-1299

[9]

LARCHEVEQUE M, 1989, B SOC CHIM FR, P130

[10]

LARCHEVEQUE M, 1987, TETRAHEDRON LETT, V23, P1993

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