HIGH-AFFINITY BINDING-SITES FOR GASTRIN-RELEASING PEPTIDE ON HUMAN COLORECTAL-CANCER TISSUE BUT NOT UNINVOLVED MUCOSA

被引：59

作者：

PRESTON, SR ^{[1
]}

WOODHOUSE, LF ^{[1
]}

JONESBLACKETT, S ^{[1
]}

MILLER, GV ^{[1
]}

PRIMROSE, JN ^{[1
]}

机构：

[1] ST JAMES UNIV HOSP,ACAD SURG UNIT,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 05期

关键词：

COLORECTAL CANCER; BOMBESIN; GASTRIN-RELEASING PEPTIDE; NEUROMEDIN B; RECEPTORS;

D O I：

10.1038/bjc.1995.210

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human colorectal cancer tissue and matched uninvolved mucosa from 21 patients were examined by radioligand displacement for the presence of binding sites for bombesin-like peptides. Five cancers, but no univolved mucosa, expressed high-affinity, low-capacity bombesin binding sites (K-d = 6.53 nM, B-max = 58.6 fmol mg(-1) protein) of the gastrin-releasing peptide (GRP)-preferring subtype (IC50 4.8 nM). Bombesin-like peptides may have a role in the pathogenesis of colorectal cancer, and bombesin receptor antagonists may be of value in the treatment of receptor-positive tumours.

引用

页码：1087 / 1089

页数：3

共 23 条

[1]

FATHI Z, 1993, J BIOL CHEM, V268, P5979

[2] IDENTIFICATION OF A CHROMOSOME-18Q GENE THAT IS ALTERED IN COLORECTAL CANCERS [J].

FEARON, ER ;

CHO, KR ;

NIGRO, JM ;

KERN, SE ;

SIMONS, JW ;

RUPPERT, JM ;

HAMILTON, SR ;

PREISINGER, AC ;

THOMAS, G ;

KINZLER, KW ;

VOGELSTEIN, B .

SCIENCE, 1990, 247 (4938) :49-56

[3] CHARACTERIZATION, IN SOME HUMAN BREAST-CANCER CELL-LINES, OF GASTRIN-RELEASING PEPTIDE-LIKE RECEPTORS WHICH ARE ABSENT IN NORMAL BREAST EPITHELIAL-CELLS [J].

GIACCHETTI, S ;

GAUVILLE, C ;

DECREMOUX, P ;

BERTIN, L ;

BERTHON, P ;

ABITA, JP ;

CUTTITTA, F ;

CALVO, F .

INTERNATIONAL JOURNAL OF CANCER, 1990, 46 (02) :293-298

[4] CARCINOMA OF THE PROSTATE [J].

GITTES, RF .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (04) :236-245

[5] IDENTIFICATION OF A GENE LOCATED AT CHROMOSOME-5Q21 THAT IS MUTATED IN COLORECTAL CANCERS [J].

KINZLER, KW ;

NILBERT, MC ;

VOGELSTEIN, B ;

BRYAN, TM ;

LEVY, DB ;

SMITH, KJ ;

PREISINGER, AC ;

HAMILTON, SR ;

HEDGE, P ;

MARKHAM, A ;

CARLSON, M ;

JOSLYN, G ;

GRODEN, J ;

WHITE, R ;

MIKI, Y ;

MIYOSHI, Y ;

NISHISHO, I ;

NAKAMURA, Y .

SCIENCE, 1991, 251 (4999) :1366-1370

[6] IDENTIFICATION OF FAP LOCUS GENES FROM CHROMOSOME-5Q21 [J].

KINZLER, KW ;

NILBERT, MC ;

SU, LK ;

VOGELSTEIN, B ;

BRYAN, TM ;

LEVY, DB ;

SMITH, KJ ;

PREISINGER, AC ;

HEDGE, P ;

MCKECHNIE, D ;

FINNIEAR, R ;

MARKHAM, A ;

GROFFEN, J ;

BOGUSKI, MS ;

ALTSCHUL, SF ;

HORII, A ;

ANDO, H ;

MIYOSHI, Y ;

MIKI, Y ;

NISHISHO, I ;

NAKAMURA, Y .

SCIENCE, 1991, 253 (5020) :661-665

[7] MUTATIONS OF A MUTS HOMOLOG IN HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER [J].

LEACH, FS ;

NICOLAIDES, NC ;

PAPADOPOULOS, N ;

LIU, B ;

JEN, J ;

PARSONS, R ;

PELTOMAKI, P ;

SISTONEN, P ;

AALTONEN, LA ;

NYSTROMLAHTI, M ;

GUAN, XY ;

ZHANG, J ;

MELTZER, PS ;

YU, JW ;

KAO, FT ;

CHEN, DJ ;

CEROSALETTI, KM ;

FOURNIER, REK ;

TODD, S ;

LEWIS, T ;

LEACH, RJ ;

NAYLOR, SL ;

WEISSENBACH, J ;

MECKLIN, JP ;

JARVINEN, H ;

PETERSEN, GM ;

HAMILTON, SR ;

GREEN, J ;

JASS, J ;

WATSON, P ;

LYNCH, HT ;

TRENT, JM ;

DELACHAPELLE, A ;

KINZLER, KW ;

VOGELSTEIN, B .

CELL, 1993, 75 (06) :1215-1225

[8] CHARACTERIZATION OF A GASTRIN RELEASING PEPTIDE FROM PORCINE NON-ANTRAL GASTRIC TISSUE [J].

MCDONALD, TJ ;

JORNVALL, H ;

NILSSON, G ;

VAGNE, M ;

GHATEI, M ;

BLOOM, SR ;

MUTT, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 90 (01) :227-233

[9]

MINAMINO N, 1983, BIOCHEM BIOPH RES CO, V114, P241

[10]

NARAYAN S, 1990, CANCER RES, V50, P6772

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