ANTIBODIES TO POLYNUCLEOTIDES - DISTRIBUTION IN HUMAN SERUMS

被引：164

作者：

KOFFLER, D

CARR, RI

AGNELLO, V

FIEZI, T

KUNKEL, HG

机构：

来源：

SCIENCE | 1969年 / 166卷 / 3913期

关键词：

D O I：

10.1126/science.166.3913.1648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hemagglutination procedures were used to determine the distribution of antibodies to native DNA, single-stranded DNA, and doublestranded RNA. Antibodies to all three polynucleotides were found in a high percentage of the serums of patients. with systemic lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of patients in the active stages of systemic lupus erythematosus, whereas antibodies to singlestranded DNA were observed in the serums of patients with several diseases and of some normal individuals.

引用

页码：1648 / &

共 17 条

[1]

BURNS RM, 1966, P SOC EXP BIOL MED, V122, P714, DOI 10.3181/00379727-122-31234

[2]

CARR RI, 1969, CLIN EXP IMMUNOL, V4, P527

[3]

CEPELLINI R, 1957, P SOC EXP BIOL MED, V96, P572

[4] ANTIBODIES SPECIFIC FOR RIBONUCLEOSIDES + RIBONUCLEOTIDES + THEIR REACTION WITH DNA [J].