CARCINOGEN-INDUCED IMMUNE DEPRESSION - ABSENCE IN MICE RESISTANT TO CHEMICAL ONCOGENESIS

被引：56

作者：

STUTMAN, O

机构：

[1] Department of Laboratory Medicine, College of Medical Sciences, University of Minnesota, Minneapolis, MN

来源：

SCIENCE | 1969年 / 166卷 / 3905期

关键词：

D O I：

10.1126/science.166.3905.620

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Administration of 3-methylcholanthrene 6 days before antigenic challenge depressed the immune response to sheep red cells in young adult mice (C3Hf/Bi strain) sensitive to the oncogenic effect of the drug (100 percent local tumors 240 days after carcinogen). The drug was not immunodepressant in the 1 strain, which is relatively resistant to its carcinogenic effect (11 percent local tumor's 240 days after carcinogen).

引用

页码：620 / &

共 33 条

[1]

ALEXANDER P, 1968, PROG EXP TUMOR RES, V10, P22

[2] PROLONGED IMMUNOSUPPRESSION AND TUMOR INDUCTION BY A CHEMICAL CARCINOGEN INJECTED AT BIRTH [J].