TRIPLET-STATE CHARGE-TRANSFER REACTION BETWEEN PARA-NITROACETOPHENONE AND GUANOSINE-MONOPHOSPHATE - POSSIBLE MECHANISM FOR ELECTRON-AFFINIC RADIOSENSITIZATION

被引：12

作者：

SMITH, GJ

机构：

[1] Department of Scientific and Industrial Research, Physics and Engineering Laboratory, Lower Hutt, Private Bag

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1979年 / 35卷 / 03期

关键词：

D O I：

10.1080/09553007914550301

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Using flash photolysis it has been observed that the triplet state of p-nitroacetophenone reacts rapidly with guanosine monophosphate to give the p-nitroacetophenone radical anion, and presumably the guanine radical cation is also formed in this reaction. From this observation, it is predicted by theory that a similar reaction will occur between p-nitroacetophenone and the triplet state of guanosine monophosphate. Because guanine is excited to its triplet state when DNA is irradiated with X-rays, it is suggested that the charge transfer reaction between p-nitroacetophenone and the triplet state of guanine contributes to the radiosensitizing action of p-nitroacetophenone. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：265 / 271

页数：7

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