LONG-RANGE RESTRICTION SITE MAPPING OF A SYNTENIC SEGMENT CONSERVED BETWEEN HUMAN CHROMOSOME-1 AND MOUSE CHROMOSOME-3

被引：40

作者：

KINGSMORE, SF ^{[1
]}

MOSELEY, WS ^{[1
]}

WATSON, ML ^{[1
]}

SABINA, RL ^{[1
]}

HOLMES, EW ^{[1
]}

SELDIN, MF ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT MICROBIOL & IMMUNOL,DURHAM,NC 27710

来源：

GENOMICS | 1990年 / 7卷 / 01期

关键词：

D O I：

10.1016/0888-7543(90)90520-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A linkage map determined from segregation analysis of 338 meiotic events in an interspecific mouse cross was utilized to help investigate genomic organization of a linkage group conserved between human chromosome 1p and mouse chromosome 3. Using pulsedfield gel electrophoresis, the genes encoding the lymphocyte adhesion molecule human CD2/murine Ly-37, the α1-subunit of Na, K-ATPase, the β-subunit of thyrotropin, the β-subunit of nerve growth factor, and muscle adenylate deaminase were similarly positioned on long-range restriction maps in both species. These studies indicate that the development of detailed genetic maps using interspecific Mus crosses facilitates rapid analysis of murine genomic organization and may enable physical mapping of syntenic regions within the human genome. Moreover, the data suggest profound conservation of genomic organization during mammalian evolution. © 1990.

引用

页码：75 / 83

页数：9

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