INVESTIGATION OF THE EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND BLOOD GROUP-A ANTIGEN IN 110 HUMAN GLIOMAS

被引：13

作者：

JONES, NR ^{[1
]}

ROSSI, ML ^{[1
]}

GREGORIOU, M ^{[1
]}

HUGHES, JT ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT ZOOL,MOLEC BIOPHYS LAB,OXFORD,ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1990年 / 16卷 / 03期

关键词：

astrocytoma; blood group antigens; blood vessels; epidermal growth factor receptor; glioma; immunohistochemistry; monoclonal antibodies; tumour antigens;

D O I：

10.1111/j.1365-2990.1990.tb01155.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Investigation of the expression of epidermal growth factor receptor and blood group A antigen in 110 human gliomas. The presence of epidermal growth factor receptor (EGF‐R) and blood group A antigen was studied immunohistochemically in a series of 110 malignant gliomas using monoclonal antibodies. Fifty‐seven percent of the tumours strongly expressed EGF‐R on the malignant cells. Although blood group A antigen is present on EGF‐R of A431 cells (a cell line derived from a human epidermoid carcinoma), in gliomas it was found only on vascular endothelial cells of tumours from blood group A patients. The results suggest that the EGF‐R present in gliomas differs from that in A431 cells in the type or amount of the carbohydrate chains. This is in contrast to previous reports which have suggested that A antigen is present on EGF‐R in gliomas. This has relevance in the choice of monoclonal antibodies used to study the EGF‐R, as those directed against the A antigen component of the A431 cell EGF‐R will not recognize EGF‐R elsewhere and may cause normal blood group A antigen to be mistaken for EGF‐R. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：185 / 192

页数：8

共 37 条

[1] IMMUNOHISTOLOGIC PATTERNS OF 32 ANTI-A MONOCLONAL-ANTIBODIES IN NORMAL HUMAN PYLORIC AND DUODENAL MUCOSAE [J].

BARA, J ;

MOLLICONE, R ;

MOURADIAN, P ;

ORIOL, R .

REVUE FRANCAISE DE TRANSFUSION ET IMMUNO-HEMATOLOGIE, 1987, 30 (05) :455-463

[2]

BONFIGLIO TA, 1976, ARCH PATHOL LAB MED, V100, P307

[3] SUBCELLULAR-DISTRIBUTION OF THE EXTERNAL AND INTERNAL DOMAINS OF THE EGF RECEPTOR IN A-431 CELLS [J].

CARPENTIER, JL ;

REES, AR ;

GREGORIOU, M ;

KRIS, R ;

SCHLESSINGER, J ;

ORCI, L .

EXPERIMENTAL CELL RESEARCH, 1986, 166 (02) :312-326

[4] BLOOD GROUP-ACTIVE CARBOHYDRATE CHAINS ON THE RECEPTOR FOR EPIDERMAL GROWTH-FACTOR OF A431-CELLS [J].

CHILDS, RA ;

GREGORIOU, M ;

SCUDDER, P ;

THORPE, SJ ;

REES, AR ;

FEIZI, T .

EMBO JOURNAL, 1984, 3 (10) :2227-2233

[5]

CLAUSEN H, 1986, J IMMUNOL, V136, P326

[6]

DAVIDSOHN I, 1969, AM J PATHOL, V57, P307

[7] A431-CELL VARIANTS LACKING THE BLOOD GROUP-A ANTIGEN DISPLAY INCREASED HIGH-AFFINITY EPIDERMAL GROWTH FACTOR-RECEPTOR NUMBER, PROTEIN-TYROSINE KINASE-ACTIVITY, AND RECEPTOR TURNOVER [J].

DEFIZE, LHK ;

ARNDTJOVIN, DJ ;

JOVIN, TM ;

BOONSTRA, J ;

MEISENHELDER, J ;

HUNTER, T ;

DEHEY, HT ;

DELAAT, SW .

JOURNAL OF CELL BIOLOGY, 1988, 107 (03) :939-949

[8]

ENGLAND DM, 1979, ARCH PATHOL LAB MED, V103, P586

[9] ANTIBODY GUIDED IRRADIATION OF BRAIN GLIOMA BY ARTERIAL INFUSION OF RADIOACTIVE MONOCLONAL-ANTIBODY AGAINST EPIDERMAL GROWTH-FACTOR RECEPTOR AND BLOOD GROUP-A ANTIGEN [J].

EPENETOS, AA ;

COURTENAYLUCK, N ;

PICKERING, D ;

HOOKER, G ;

DURBIN, H ;

LAVENDER, JP ;

MCKENZIE, CG .

BRITISH MEDICAL JOURNAL, 1985, 290 (6480) :1463-1466

[10] NERVE GROWTH-FACTOR RECEPTORS ON HUMAN MELANOMA CELLS IN CULTURE [J].

FABRICANT, RN ;

DELARCO, JE ;

TODARO, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) :565-569

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