ANTIALLERGY ACTIVITY OF SUBSTITUTED 11-OXO-H-11-PYRIDO[2,1-B]QUINAZOLINE-8-CARBOXYLIC ACIDS

被引：40

作者：

SCHWENDER, CF ^{[1
]}

SUNDAY, BR ^{[1
]}

HERZIG, DJ ^{[1
]}

KUSNER, EK ^{[1
]}

SCHUMANN, PR ^{[1
]}

GAWLAK, DL ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,DEPT PHARMACOL,DIV PHARMACEUT RES,ANN ARBOR,MI

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 06期

关键词：

D O I：

10.1021/jm00192a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted ll-oxo-llH-pvrido[2, l-b]quinazoline-8-carboxylic acids were prepared and evaluated as antiallergy agents. Several analogues were orally active. 2-Methyl-11-oxo-11H-pyrido[2, l-b]quinoazoline-8-carboxylic acid (6) was superior to cromolyn sodium and doxantrazole orally and intravenously in the rat PCA test and a rat allergic bronchospasm model. © 1979, American Chemical Society. All rights reserved.

引用

页码：748 / 750

页数：3

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