ENHANCEMENT OF EXPERIMENTAL RESPIRATORY-INFECTION FOLLOWING NICKEL INHALATION

被引：34

作者：

ADKINS, B ^{[1
]}

RICHARDS, JH ^{[1
]}

GARDNER, DE ^{[1
]}

机构：

[1] US EPA,HLTH EFFECTS RES LAB,RES TRIANGLE PK,NC 27711

来源：

ENVIRONMENTAL RESEARCH | 1979年 / 20卷 / 01期

关键词：

D O I：

10.1016/0013-9351(79)90083-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effects of nickel chloride inhalation on the enhancement of experimentally induced streptococcal infections were studied. Exposure to nickel chloride (499.2 μg Ni/m3) for 2 hr produced significant enhancement in mortality. This response was observed for 24 hr after the nickel chloride exposure. A delayed clearance response of inhaled streptococci, also observed in the nickel-treated mice, supported the mortality data. Several parameters involving pulmonary cells obtained by in situ lavage 24 hr after nickel chloride exposure were also studied; no reduction in total cell yield, viability, or cellular composition was observed. A significant reduction in phagocytic capability, as compared to that of control animal cells, was observed in alveolar macrophages obtained 24 hr after nickel chloride exposure. © 1979.

引用

页码：33 / 42

页数：10

共 22 条

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