COMPARING THE GLYCOSYLATION PATTERNS OF RECOMBINANT GLYCOPROTEINS

被引：18

作者：

PAREKH, RB

PATEL, TP

机构：

[1] R. B. Parekh and T. P. Patel are, Oxford GlycoSystems Ltd, Unit 4, Abingdou, Oxon OX14 1RG, Hitching Court, Blacklands Way

来源：

TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 08期

关键词：

D O I：

10.1016/0167-7799(92)90244-P

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The glycosylation profile of a recombinant glycoprotein can not only significantly affect its therapeutic profile, but is also extremely sensitive to cell-culture and purification conditions. To define glycosylation patterns and to ensure consistency of recombinant glycoproteins among different preparations requires highly sensitive and reproducible analytical methods that can be used routinely. New strategies and instrumentation are being developed which should allow such analysis to be largely automated.

引用

页码：276 / 280

页数：5

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