FAT IN BONE XENOGRAFTS - IMPORTANCE OF THE PURIFICATION PROCEDURES ON CLEANLINESS, WETTABILITY AND BIOCOMPATIBILITY

被引：56

作者：

CHAPPARD, D ^{[1
]}

FRESSONNET, C ^{[1
]}

GENTY, C ^{[1
]}

BASLE, MF ^{[1
]}

REBEL, A ^{[1
]}

机构：

[1] LAB BIOL TISSU OSSEUX, ST ETIENNE, FRANCE

来源：

BIOMATERIALS | 1993年 / 14卷 / 07期

关键词：

BONE; GRAFTING; IMPLANTS; STEREOLOGICAL PROCEDURE; BONE MORPHOMETRY;

D O I：

10.1016/0142-9612(93)90238-W

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Xenografting is a promising alternative to allografts and autografts. The remaining lipids in bone are known to influence the biocompatibility. A comparative study of wettability was done on standardized blocks of two biomaterials. A highly purified and defatted bovine bone graft (T650) was found to retain more water (2.06 g/block) than a less defatted biomaterial (T360, 0.3 g/block). Wettability, observed in the laboratory, may reflect an important in vivo property: the rapidity for extracellular fluids and blood cells to invade the graft and carry bone forming cells. When implanted in rabbit cancellous bone, T650 appears to be osteoconductive in a manner that allows trabecular architecture to be restored within 6 months.

引用

页码：507 / 512

页数：6

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