MERIDAMYCIN - A NOVEL NONIMMUNOSUPPRESSIVE FKBP12 LIGAND FROM STREPTOMYCES-HYGROSCOPICUS

被引：29

作者：

SALITURO, GM

ZINK, DL

DAHL, A

NIELSEN, J

WU, E

HUANG, LY

KASTNER, C

DUMONT, FJ

机构：

[1] MERCK RES LABS,DEPT MICROBIAL BIOCHEM & PROC RES,RAHWAY,NJ 07065

[2] MERCK RES LABS,DEPT MICROBIAL CHEMOTHERAPEUT & MOLEC GENET,RAHWAY,NJ 07065

[3] MERCK RES LABS,DEPT IMMUNOL RES,RAHWAY,NJ 07065

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02425-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, 27-membered macrolide, meridamycin, was isolated from a strain of Streptomyces hygroscopicus and found to inhibit the binding of FK-506 to FKBP12 and to antagonize the immunosuppressive activity of both FK-506 and rapamycin. The isolation, structure elucidation, and biological activity of this compound are described in this paper.

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页码：997 / 1000

页数：4

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