INTRACEREBROVENTRICULAR INTERLEUKIN-1 RECEPTOR ANTAGONIST BLOCKS THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY INESCAPABLE SHOCK

被引：150

作者：

MAIER, SF ^{[1
]}

WATKINS, LR ^{[1
]}

机构：

[1] UNIV COLORADO,DEPT PSYCHOL,BOULDER,CO 80309

来源：

BRAIN RESEARCH | 1995年 / 695卷 / 02期

关键词：

INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; INTRACEREBROVENTRICULAR; RAT; STRESS; ESCAPE; FEAR; LEARNED HELPLESSNESS;

D O I：

10.1016/0006-8993(95)00930-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain interleukin-1 (IL-1) plays a key role in mediating the neural, endocrine, and behavioral consequences of injury and infection. Recent evidence indicates that brain IL-1 may also be important in producing endocrine and neurochemical responses to stressors. The present experiment sought to determine whether intracerebroventricular (i.c.v.) administration of an interleukin-1 receptor antagonist (IL-1ra) would block behavioral effects of a stressor. I.c.v. application of hrIL-1ra before inescapable shock blocked the subsequent intereference with escape learning and enhancement of fear conditioning normally produced by this treatment.

引用

页码：279 / 282

页数：4

共 31 条

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