Dynamic epidermal cooling in conjunction with laser treatment of port-wine stains: Theoretical and preliminary clinical evaluations

被引：27

作者：

Anvari, B

Milner, TE

Tanenbaum, BS

Kimel, S

Svaasand, LO

Nelson, JS

机构：

[1] HARVEY MUDD COLL, DEPT ENGN, CLAREMONT, CA 91711 USA

[2] HARVEY MUDD COLL, DEPT PHYS, CLAREMONT, CA 91711 USA

[3] TECHNION ISRAEL INST TECHNOL, DEPT CHEM, IL-32000 HAIFA, ISRAEL

[4] UNIV TRONDHEIM, NORWEGIAN INST TECHNOL, DIV PHYS ELECT, N-7034 TRONDHEIM, NORWAY

来源：

LASERS IN MEDICAL SCIENCE | 1995年 / 10卷 / 02期

关键词：

epidermal thermal injury; infra-red radiometry; refrigerant; selective cooling; selective photothermolysis; tetrafluoroethane; vascular abnormalities; port-wine stain;

D O I：

10.1007/BF02150847

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The clinical objective in laser treatment of port-wine stains (PWS) is to induce selective photothermolysis of subsurface blood vessels without damaging the overlying epidermis. This paper investigates the effectiveness of 'dynamic' cooling, where a cryogen is sprayed on the skin surface for an appropriately short period of time, to eliminate epidermal thermal injury during laser treatment of PWS. Comparative measurements of radiometric surface temperature from cooled and uncooled laser irradiated (585 nm) PWS sites, and theoretical predictions of temperature distributions within skin in response to dynamic cooling in conjunction with laser irradiation are presented. Rapid reduction of skin surface temperature and localization of cooling the epidermis are obtained when a cryogen is sprayed on skin prior to laser irradiation. Successful blanching of the PWS without thermal injury to the overlying epidermis is accomplished.

引用

页码：105 / 112

页数：8

共 21 条

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