HIV-INHIBITORY NATURAL-PRODUCTS .23. A REINVESTIGATION OF MAPROUNEA TRITERPENES

被引：17

作者：

BEUTLER, JA ^{[1
]}

KASHMAN, Y ^{[1
]}

TISCHLER, M ^{[1
]}

CARDELLINA, JH ^{[1
]}

GRAY, GN ^{[1
]}

CURRENS, MJ ^{[1
]}

WALL, ME ^{[1
]}

WANI, MC ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI, DIV CANC TREATMENT, DEV THERAPEUT PROGRAM, DRUG DISCOVERY RES & DEV LAB, FREDERICK, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 07期

关键词：

D O I：

10.1021/np50121a008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group.

引用

页码：1039 / 1046

页数：8

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