MYOSITIS-OSSIFICANS PROGRESSIVA - CLINICAL AND METABOLICAL OBSERVATIONS IN A CASE TREATED WITH A DIPHOSPHONATE (EHDP) AND SURGICAL REMOVAL OF ECTOPIC BONE

被引：15

作者：

HOLMSEN, H

LJUNGHALL, S

HIERTON, T

机构：

[1] UNIV UPPSALA HOSP,DEPT INTERNAL MED,S-75014 UPPSALA,SWEDEN

[2] UNIV UPPSALA HOSP,DEPT ORTHOPED SURG,S-75014 UPPSALA,SWEDEN

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1979年 / 50卷 / 01期

关键词：

Diphosphonate (EHDP); Metabolism; Myositis ossificans pro-gessiva; Surgery;

D O I：

10.3109/17453677909024087

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

A 20-year-old woman with a severely crippling myositis ossificans progressiva was treated with a diphosphonate (EHDP), 10-20 mg/kg/day. While being treated with this drug, surgical removal of ectopic bone was performed. Although ectopic calcification recurred postoperatively, considerable functional improvement was achieved. At the highest dosage of EHDP, hypercalcaemia gradually appeared, but was reversible upon cessation of drug treatment. It is probably related to a direct effect of EHDP on the bone. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：33 / 38

页数：6

共 19 条

[1]

BASSETT CAL, 1969, LANCET, V2, P845

[2] INHIBITION OF VITAMIN-D METABOLISM BY ETHANE-1-HYDROXY-1, 1-DIPHOSPHONATE [J].