THE INHIBITION SITE OF MPP+, THE NEUROTOXIC BIOACTIVATION PRODUCT OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE IS NEAR THE Q-BINDING SITE OF NADH DEHYDROGENASE

被引：97

作者：

RAMSAY, RR

KOWAL, AT

JOHNSON, MK

SALACH, JI

SINGER, TP

机构：

[1] VET ADM MED CTR,DIV MOLEC BIOL,4150 CLEMENT ST,SAN FRANCISCO,CA 94121

[2] UNIV GEORGIA,DEPT CHEM,ATHENS,GA 30601

[3] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1987年 / 259卷 / 02期

关键词：

D O I：

10.1016/0003-9861(87)90531-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：645 / 649

页数：5

共 17 条

[11] UPTAKE OF THE NEUROTOXIN 1-METHYL-4-PHENYLPYRIDINE (MPP+) BY MITOCHONDRIA AND ITS RELATION TO THE INHIBITION OF THE MITOCHONDRIAL OXIDATION OF NAD+-LINKED SUBSTRATES BY MPP+ [J].

RAMSAY, RR ;

SALACH, JI ;

SINGER, TP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (02) :743-748

[12] INHIBITION OF MITOCHONDRIAL NADH DEHYDROGENASE BY PYRIDINE-DERIVATIVES AND ITS POSSIBLE RELATION TO EXPERIMENTAL AND IDIOPATHIC PARKINSONISM [J].

RAMSAY, RR ;

SALACH, JI ;

DADGAR, J ;

SINGER, TP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 135 (01) :269-275

[13] ENZYMATIC PROPERTIES OF INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIA [J].

SCHNAITMAN, C ;

GREENAWALT, JW .

JOURNAL OF CELL BIOLOGY, 1968, 38 (01) :158-+

[14]

Singer T P, 1974, Methods Biochem Anal, V22, P123, DOI 10.1002/9780470110423.ch3

[15] INTERACTIONS OF THE NEUROTOXIC AMINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE WITH MONOAMINE OXIDASES [J].

SINGER, TP ;

SALACH, JI ;

CASTAGNOLI, N ;

TREVOR, A .

BIOCHEMICAL JOURNAL, 1986, 235 (03) :785-789

[16] BIOCHEMICAL EVENTS IN THE DEVELOPMENT OF PARKINSONISM INDUCED BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

SINGER, TP ;

CASTAGNOLI, N ;

RAMSAY, RR ;

TREVOR, AJ .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (01) :1-8

[17] STUDIES ON THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - INHIBITION OF NAD-LINKED SUBSTRATE OXIDATION BY ITS METABOLITE, 1-METHYL-4-PHENYLPYRIDINIUM [J].

VYAS, I ;

HEIKKILA, RE ;

NICKLAS, WJ .

JOURNAL OF NEUROCHEMISTRY, 1986, 46 (05) :1501-1507

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