IMMUNOREACTIVE SOMATOSTATIN RELEASE FROM RAT SPINAL-CORD INVITRO

被引：22

作者：

SHEPPARD, M

KRONHEIM, S

ADAMS, C

PIMSTONE, B

机构：

[1] Isotope and Immunoassay Laboratory, Department of Medicine, University of Cape Towm Medical School

来源：

NEUROSCIENCE LETTERS | 1979年 / 15卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0304-3940(79)91531-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A calcium-dependent release of immunoreactive somatostatin from rat spinal cord in vitro in response to two depolarising stimuli (60 mM KCl and 75 μM veratrine) has been demonstrated. Released somatostatin immunoreactivity comprised 0.53% of total tissue content, showed parallelism when serial dilutions were compared to the immunoassay dose-response curve and eluted similarly to synthetic somatostatin on Sephadex G-25 (f) chromatography. T These results provide further evidence for a neurotransmitter or neuromodulator role for somatostatin in mammalian spinal cord. © 1979.

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收藏

页码：65 / 70

页数：6

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