PROSTAGLANDINS E1 AND E2 ANTAGONIZE NOREPINEPHRINE EFFECTS ON CEREBELLAR PURKINJE CELLS - MICROELECTROPHORETIC STUDY

被引：55

作者：

HOFFER, BJ

SIGGINS, GR

BLOOM, FE

机构：

[1] Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington

来源：

SCIENCE | 1969年 / 166卷 / 3911期

关键词：

D O I：

10.1126/science.166.3911.1418

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In microelectrophoretic experiments, prostaglandins E1 and E2 antagonize the reduction in discharge rate of cerebellar Purkinje cells produced by norepinephrine. Slowing of discharge evoked by 3′,5′-adenosine monophosphate or gamma aminobutyric acid is not antagonized. These data provide the first indication that endogenous prostaglandins may physiologically function to modulate central noradrenergic junctions.

引用

页码：1418 / &

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