PRODUCTION AND METABOLIC-CLEARANCE OF 1,25-DIHYDROXYVITAMIN-D IN MEN - EFFECT OF ADVANCING AGE

被引:37
作者
HALLORAN, BP
PORTALE, AA
LONERGAN, ET
MORRIS, RC
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, GEN CLIN RES CTR, SAN FRANCISCO, CA 94143 USA
[4] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA
[5] UNIV CALIF SAN FRANCISCO, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USA
关键词
D O I
10.1210/jcem-70-2-318
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine whether aging alters the metabolism of 1, 25-dihydroxyvitamin D [1, 25-(OH)2D] in men, we measured the serum concentrations, MCRs, and production rates of 1, 25-(OH)2D in healthy old (age, 72 ± 5 yr; n = 9) and young men (age, 34 ± 5 yr; n = 9) consuming a constant metabolic diet and in whom the glomerular filtration rate was greater than 1.2 mL/s·1.73 m-2. The results indicate that when dietary calcium and phosphorus are normal and glomerular filtration rate is not reduced, the serum concentrations, MCRs, and production rates of 1, 25-(OH)2D in old men [83 ± 22 pmol/L; 0.62 ± 0.10 mL/s·70 kg ideal BW (IBW); 51 ± 12 fmol/s·70 kg IBW, respectively] and young men (90 ± 20 pmol/L; 0.56 ± 0.09 mL/s·70 kg IBW; 52 ± 13 fmol/s·70 kg IBW, respectively) are equivalent. Indices of serum PTH, however, were elevated in the elderly men. These results suggest that aging per se has little or no effect on the serum concentration, MCR, or production rate of 1, 25-(OH)2D in men. Maintenance of a normal production rate of 1, 25-(OH)2D in elderly men, however, may require increased circulating PTH. Most observed declines in serum 1, 25-(OH)2D in elderly men are probably a consequence of decreased functional renal mass. © 1990 by The Endocrine Society.
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页码:318 / 323
页数:6
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