OPIATE-LIKE ACTIVITY OF SALSOLINOL ON THE ELECTRICALLY STIMULATED GUINEA-PIG ILEUM

被引：36

作者：

HAMILTON, MG

HIRST, M

BLUM, K

机构：

[1] UNIV WESTERN ONTARIO,DEPT PHARMACOL,LONDON N6A 3K7,ONTARIO,CANADA

[2] UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284

来源：

LIFE SCIENCES | 1979年 / 25卷 / 26期

关键词：

D O I：

10.1016/0024-3205(79)90093-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Contractions elicited by electrical stimulation of the guinea pig ileum are reduced partially by the tetrahydroisoquinoline compound, salsolinol. This action is antagonized by pretreatment with the narcotic antagonist, naloxone, but not reversed by this agent once the effect is initiated. In addition, salsolinol can reduce the inhibitory activity of morphine. These results suggest that salsolinol may be a partial agonist on this opiate-sensitive preparation. © 1979.

引用

页码：2205 / 2210

页数：6

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