ACTIVITIES OF VARIOUS MACROLIDE ANTIBIOTICS AGAINST MYCOBACTERIUM-LEPRAE INFECTION IN MICE

被引：31

作者：

GELBER, RH

SIU, P

TSANG, M

MURRAY, LP

机构：

[1] Kuzell Institute for Arthritis, San Francisco Med. Res. Inst., San Francisco, CA 94115-1896

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 04期

关键词：

D O I：

10.1128/AAC.35.4.760

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.

引用

页码：760 / 763

页数：4

共 24 条

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[2]

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[3]

COLSTON MJ, 1978, LEPROSY REV, V49, P7

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