POSTTRANSCRIPTIONAL REGULATION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-2 MESSENGER-RNA IN DIABETIC RAT-LIVER

被引：22

作者：

OOI, GT

TSENG, LYH

RECHLER, MM

机构：

[1] Growth and Development Section, Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)92307-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1. © 1992.

引用

页码：1031 / 1037

页数：7

共 26 条

[1] ARMITAGE P, 1987, STATISTICAL METHODS
[2] FOCAL INDUCTION OF IGF BINDING-PROTEINS IN PROXIMAL TUBULES OF DIABETIC RAT-KIDNEY
BACH, LA
COX, AJ
MENDELSOHN, FAO
HERINGTON, AC
WERTHER, GA
JERUMS, G
[J]. DIABETES, 1992, 41 (04) : 499 - 507
[3] REGULATION OF HEPATIC EXPRESSION OF IGF-I AND FETAL IGF BINDING-PROTEIN MESSENGER-RNA IN STREPTOZOTOCIN-DIABETIC RATS
BONISCHNETZLER, M
BINZ, K
MARY, JL
SCHMID, C
SCHWANDER, J
FROESCH, ER
[J]. FEBS LETTERS, 1989, 251 (1-2) : 253 - 256
[4] BROWN AL, 1989, J BIOL CHEM, V264, P5148
[5] BROWN AL, 1986, J BIOL CHEM, V261, P3144
[6] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[7] VARIABLES CONTROLLING THE SECRETION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-2 IN NORMAL HUMAN-SUBJECTS
CLEMMONS, DR
SNYDER, DK
BUSBY, WH
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (04) : 727 - 733
[8] REGULATION OF GENE-EXPRESSION BY INSULIN IN ADIPOSE-CELLS - OPPOSITE EFFECTS ON ADIPSIN AND GLYCEROPHOSPHATE DEHYDROGENASE GENES
DANI, C
BERTRAND, B
BARDON, S
DOGLIO, A
AMRI, E
GRIMALDI, P
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1989, 63 (1-2) : 199 - 208
[9] FATTAL PG, 1992, J BIOL CHEM, V267, P12412
[10] LUO JM, 1991, MOL CELL BIOCHEM, V103, P41

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